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Listen in as we dive deep into the science of appetite suppression and the $20M research investment that produced the world’s first clinically proven, patented natural GLP-1 activator.

What Practitioners Should Know About Natural GLP-1 Activators

With a reported 49% of US adults now interested in trying a GLP-1 medication - even to lose only a few pounds - it is the perfect time to ask a simple question: Is there a natural way to boost GLP-1 production sufficiently to serve the needs of many of those lining up for Ozempic and other semaglutides?
 

It turns out that when the New Zealand government decided to confront its obesity epidemic, they approached it first by seeking answers to this very question. After $20M of government funded research and 1,000 plant compounds tested on cells harvested from the human digestive tract, they discovered that the answer is yes to a natural alternative.

 

Out of this research has emerged the world’s first patented and clinically proven natural product to boost GLP-1 production sufficiently to curb a person’s appetite and provide an enormous advantage to anyone seeking to lose weight without the risk of side effects from more potent pharmaceutical approaches. 

 

Join OvationLab on Wednesday, February 28th at 7 pm ET/4 PM PT for this timely and clinically important discussion with lead nutraceutical weight management  research scientist Ed Walker, PhD alongside obesity medicine specialist, Michelle Pearlman, MD - one of the first US physicians to begin using CaloCurb in her clinical practice.

Suggested Use

The standard recommendation is to take one capsule daily for 2-3 days and build up to two capsules 1 hour prior to a meal. Up to four capsules can be taken per day

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Dosing may be tailored depending on a patients requirements such as a specific diet or hunger times. Up to 4 capsules can be taken to reach the recommended dose.

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Statements & Warnings

Due to the nature of the human clinical trials, results are based on adult dietary intake. This product is intended for adults only.

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Calocurb should not be taken by individuals that have any form of gastrointestinal inflammation or inflammatory bowel disease, such as Crohn's or ulcerative colitis. Calocurb is not indicated for patients with type 1 diabetes mellitus.

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Calocurb has also not been tested in pregnant or lactating women. In the absence of sufficient data, the use is not recommended. Calocurb is metabolized in the large intestine within 24 hours and a seminal study shows non-alcoholic beer residues in breast tissue and serum were negligible (Bolca et al., 2010). If a female patient wishes to get pregnant, she can discontinue the use of Calocurb, and it will be eliminated from her system within a short period.

Bolca, S., Li, J., Nikolic, D., Roche, N., Blondeel, P., Possemiers, S., De Keukeleire, D., Bracke, M., Heyerick, A., van Breemen, R.B. and Depypere, H. 2010. Disposition of hop prenylflavonoids in human breast tissue. Mol Nutr Food Res. 54:S284-S294.

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Known Side Effects

Taking Calocurb for the first time may cause a mild laxative effect which should cease after 24-72 hours of use. This effect is based on the presence and activity of the cells responding to the Amarasate ® stimulation which is why it is advised to build up the dosage over three days.

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Pure and Low Sensitivity

This product does NOT contain any wheat, gluten, dairy, lactose, egg, yeast, soy, artificial colours, artificial sweeteners, or artificial flavours.

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  • Who developed the active ingredient, Amarasate® in Calocurb?

    • ​Amarasate®, the active ingredient in Calocurb was developed in NZ by a group of Scientists at the largest NZ government-owned research institute, Plant and Food Research (www.plantandfood.com) over 13 years and $25m invested. Over 900 plant extracts were tested using an in-vitro enteroendocrine cell model. The most potent extract (Amarasate®) was then taken into clinical human trials.

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  • How does Calocurb compare to the latest anti-obesity medications in terms of its Mechanism of Action?

    • ​Amarasate ® stimulates the body’s own release of GLP-1 and CCK to 6 times baseline levels within an hour, lasting up to 4 hours. If Calocurb is taken one hour before a meal, the natural response to eating a meal will follow, with an enhanced appetite suppression that is slightly prolonged but gradually tapers off. This allows individuals to achieve a harmonious balance between their gut and brain appetite functions. Semaglutide injectables increase synthetic levels of GLP-1 agonists at supra-physiological concentrations, resulting in long-lasting effects due to their resistance to breakdown and do not follow the natural rhythm of hormone release.

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  • Has a weight-loss study been conducted using Calocurb?

    • A six-month weight loss study with a three-month follow-up period is planned to begin in 2023 to assess the long-term effectiveness of Calocurb as a weight loss supplement. This study is designed as a randomized, double-blind, crossover clinical trial in 150 adult  men and women with a BMI > 30.  
      It is worth noting that the GLP-1 system, which is targeted by Calocurb, has shown effectiveness for  weight management. 

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  • Does Amarasate ® have an effect on glucose levels?

    • ​The 2022 study by Walker et al. demonstrated an acute improvement in post meal glucose levels, despite no increases in insulin release. This is likely due to the gut hormones GLP-1 and CCK delaying the rate of gastric emptying resulting in slower glucose absorption into the blood. Secondly, GLP-1 can also potentiate the release of insulin relative to glucose absorption, hence improving glucose clearance from the blood.

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  • What is the bioavailability of the Amarasate ® extract used in Calocurb?

    • ​Animal studies have shown limited to nil absorption into the bloodstream; 99% of ingested hops are degraded in the lower bowel. This low bioavailability reduces the chances of interactions with other medications which are being metabolised through the liver or kidneys.

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  • How quickly does Calocurb show its effects on appetite, and how long do they last?

    • ​The effects of Calocurb are typically observed within an hour of consumption. It can reduce the feelings of hunger and cravings with clinical efficacy for up to 4 hours.

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  • Bitter extracts are sometimes used to stimulate appetite. Why does Amarasate ® not do this?

    • ​The delayed release of Amarasate ® bitter extract in the upper duodenum stimulates the activation of TAS2R receptors on enteroendocrine cells to release GLP-1, CCK and PYY (appetite suppressing hormones). The delayed release capsule avoids the gastric environment of the stomach which when stimulated by bittnerness extract, may stimulate an appetite-promoting effect.

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  • Can Calocurb cause a sedative effect?

    • ​Hops has been historically used as a mild sedative. Supercritical CO2 extraction removes almost all of the organic material from the hops, including the prenylflavonoids (e.g xanthohumols). Research shows that the sedative effect is due to the organic materials (e.g xanthohumols, myrcenols and α- and b-acid derivates) which are removed to negligible levels during the supercritical CO2 extraction to develop Amarasate.

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  • Because Amarasate ® is an extract of hops, can it have an oestrogenic effect?

    • ​Prior to supercritical CO2 extraction, hops contains organic material including the prenylated flavonoids, 8-prenylnaringenin (8-PN). 8-PN has been shown to be a potent phytoestrogen and selectively binds to estrogen α-receptors. 8-PN as well as other prenylated flavonoids are removed to negligible levels from the Amarasate ® extract following the extraction method.

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